Dimebon Mechanism of Action
Dimebon’s mechanism of action in the treatment of Alzheimer’s and Huntington’s disease is not fully understood at this time. Many intelligent scientists have created some educated hypotheses about the Dimebon mechanism of action.
The most simple statement in regards to Dimebon mechanism of action is that Dimebon works through a novel mechanism of action improving mitochondria function.
A slightly more technical mechanism of action explanation is that Dimebon has activity as an inhibitor of cholinesterase and NMDA receptors and/or inhibits neuronal death, potentially by mitochondrial-mediated inhibition of apoptosis.
One of the most comprehensive answers regarding Dimebon’s mechanism of action can be found on Wikipedia:
Dimebon (dimebolin) appears to operate through multiple mechanisms of action, both blocking the action of neurotoxic beta-amyloid proteins and inhibiting L-type calcium channels, modulating the action of AMPA and NMDA glutamate receptors, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores, which are believed to play a role in the cell death that is associated with neurodegenerative diseases and the aging process.
Dimebon’s mechanism of action will become more obvious as scientist continue to study this drug in more detail. Determining a drug’s mechanism of action can be difficult especially when it pertains to certain disease’s such as Alzheimer’s and Huntington’s disease which themselves are not well understood.